ROLE OF FLAVONOIDS IN ISCHAEMIC HEART DISEASE AS AN ADJUNCT

Abstract

Author(s): Vasudeva Ruchita*, Sharma Navdeep

Ischemic heart disease is a leading cause of morbidity and mortality. This work was undertaken with the purpose to study the effect of flavonoids in 80 patients out of a total of 100 confirmed IHD cases taken for the study. Flavonoids were given as an adjunct along with other medication for IHD. 20 patients were not given flavonoids and served as controls. The patients were selected from the wards and O.P.D. of Dept. of Medicine of Guru Nanak Dev Hospital / Government Medical College, Amritsar, India on the basis of clinical, laboratory and electrocardiographic findings. The patients’ Total serum cholesterol, S. HDL-C, S. LDL-C and S. Triglyceride were evaluated at the commencement of the study and after six months. Results were recorded and statistically analyzed. It was seen that S. cholesterol showed a definite decrease in the patients taking flavonoids and this decrease was found to be statistically significant (p value < 0.05) Also other parameters showed improvement. S. LDL-C decreased, whereas S. HDL-C increased in the patients taking flavonoids. However, the change in these parameters did not show statistical significance. Cholesterol is a major culprit in oxidative damage to coronary vessel endothelium. Hence it was concluded that this study indicates that flavonoids serve as a useful adjunct in IHD. However, to confirm their positive role in other parameters, a longer follow-up is deemed desirable.