POTENTIAL EVALUATION OF ANTI-DIARRHEAL ACTIVITY OF LEAVES OF AGANOSMA DICHOTOMA IN MICE

Abstract

Author(s): Md. Reyad-ul-Ferdous*, Md. Zahirul Islam Khan, Md. Atiqul Islam, Tamara Towshin Alam, Farzana Liza, Tazmel Haque, Subash Pandaya, Fariha Tasnim

The plant Aganosma dichotoma is widely used as traditional medicine in different aborigines which is supported by this investigation. It belongs to Apocynacae family. The aim of the study was to evaluate the methanolic extract of leaf of Aganosma dichotoma’s different fractionates as anti-diarrheal agents. The methanolic extract of leaves of Aganosma dichotoma (400 mg/kg) exhibited very statistically significant anti-diarrheal activity with a 68.27 % reduction of diarrhea compared to the standard of loperamide 69.23 %. The anti-diarrheal activity shows Aganosma dichotoma statistically significant at the higher dose compared to dose of 200 mg/kg. Therefore we can assume that, the anti-diarrheal activity of Aganosma dichotoma was dose dependent.