ISSN (Online) : 2277-4572
Author(s): Patel Piyush*1,Jivani N. P.2, Malaviya Shailesh 1
Parkinson’s disease is common hypo kinetic disorder mainly occurs by the neurodegeneration in central nervous system affecting the 2-3% of population all over the world above age 60 years. Major symptoms are tremor, rigidity, bradykinesia and posture instability. There are predisposing factor like metal exposure, family history, extreme stress and head trauma that promote the progression of Parkinson’s disease. Other risk factors includes the advanced age, environmental toxins, oxidative stress, inflammation, viral infections and intake of several dopamine antagonists play a contributory role in development of Parkinson’s disease. The Parkinson’s disease occurs due to a reduction in the striatal dopamine content in excess of 80%. The primary area of neurodegeneration in PD is the loss of dopaminergic neurons in the Substantia nigra par-compacta. Several proteins like α-synculine, ubiquitine-carboxy hydrolase terminal-1, PINK1 and DJ-1 are involved in the formation of lewis bodies which is hall mark of pathogenesis of Parkinson’s disease. Currently dopamine agonist, Monoamine oxidase A, B inhibitors are widely used for the treatment of Parkinson’s disease, although it bears the risk of adverse reaction. Now a day the medicinal plants which are less toxic and more preferred over the conventional therapeutics. In this review we have focus on pathophysiology, risk factors and possible traditional medicine useful for retarding the progression of Parkinson’s disease
