MICROWAVE-ASSISTED SYNTHESIS OF SOME BIOLOGICALLY ACTIVE PYRAZOLE DERIVATIVES

Abstract

Author(s): Swarnkar Deepak, Ameta Rakshit, Vyas Ritu

3-(4-Substituted phenyl)-5-phenyl-2,3-dihydro-1H-pyrazole (2a-c), 3-(4-substituted phenyl)-2-5-diphenyl-2,3-dihydro-1H-pyrazole (3a-c), [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine-4-yl)methanone (4a-c), [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine3-yl)methanone (5a-c) and 5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide (6a-c) have been synthesized by microwave assisted synthesis of 3-(4-Substituted phenyl)-1-phenylprop-2-en-1-ones (Chalcones) (1a-c) with hydrazine hydrate, phenyl hydrazine, isoniazide, nicotinic hydrazide or thiosemicarbezide, respectively. The synthesized compounds were characterized by IR and 1H NMR spectral data. Synthesized compounds have been estimated for probable activities using PASS (http://www.195.172.207.233/PASS).