EVALUATION OF ANTIULCER ACTIVITY OF WEDELIA CALENDULACEA AQUEOUS EXTRACT IN RODENTS

Abstract

Author(s): Gindi Sumalatha, Hwisa T Nagiat, Chandu Babu Rao* and Katakam Prakash

The present study was focused to evaluate the protective activity of the Wedelia calendulacea (WC) whole plant aqueous extract against aspirin-pylorus ligation, HCl-ethanol and water immersion stress induced ulcers. In the present study aspirin-pylorus ligation induced gastric ulcer was adopted to screen the antisecretory activity of plant extract. WC extract produced 61.76% ulcer inhibition at 400mg/kg body weight, when compared to that of standard (ranitidine, 50mg/kg) which produced 62.6% ulcer inhibition. In HCl-ethanol induced ulcer model 400mg/kg body weight of WC produced 88.87% ulcer inhibition when compared that of standard (sucralfate, 100mg/kg) which produced 90.80% ulcer inhibition. In water immersion-stress induced ulcer model 400mg/kg body weight of WC, produced 96.34% ulcer inhibition when compared to that of standard (omeprazole, 20mg/kg) which produced 99.30% ulcer inhibition. WC showed significant percentage of ulcer inhibition in the three models tested. The glycosides which are present in the aqueous extract could be responsible for their antiulcer properties.