ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ROSUVASTATIN BY USING SOLID DISPERSION TECHNIQUE

Abstract

Author(s): Swathi T*, Vamshi Krishna M, Sudheer kumar D, Krishnaveni J

The objective of the study was to increase the solubility, and dissolution rate of Rosuvastatin (RST), a poorly water-soluble 3-hydroxy3-methyl glut aryl CoA (HMG-CoA) Reductase inhibitor through solid dispersion technique. The solid dispersions were prepared by three different methods viz. melting, co grinding, surface solid dispersions and spray drying method using carriers like PEG 4000, β-cyclodextrin, microcrystalline cellulose and PVP K30. The prepared dispersions were characterized using FTIR and Differential Scanning Calorimetry. The solid dispersion prepared with PVP K30 by spray drying method exhibited greatest enhancement in solubility and fastest dissolution (98.96 % RST release in 60 minutes) of Rosuvastatin. It was observed that the solubility increased with the increase in the concentration of carrier and amongst the various methods and carriers used the solubility was Rosuvastatin was enhanced greatest with PVP K30 by spray drying method. The stability of tablets was studied and no significant changes were detected in the dissolution profile of tablets after 1 month.